Overview
Caloric restriction, senolytics, NAD+, and more — evidence-based strategies for extending healthspan and optimizing the aging process.
Longevity is no longer science fiction — researchers are identifying the fundamental mechanisms of aging and developing interventions to slow them. The nine hallmarks of aging provide a roadmap for understanding where we can intervene.
Caloric restriction (20-30% fewer calories without malnutrition) is the most consistently demonstrated intervention for extending lifespan in animal models. In humans, benefits include improved insulin sensitivity, reduced inflammation, and better aging markers. Intermittent fasting may provide similar benefits with better adherence.
Emerging therapies include NAD+ precursors (NMN and NR), senolytics (fisetin, quercetin + dasatinib), metformin, and rapamycin. While these interventions show promise in preliminary studies, most still lack long-term human clinical trials. The most prudent approach combines lifestyle-based interventions with selective supplementation.
What You Will Learn
- The 9 hallmarks of aging
- Caloric restriction and mimetics
- NAD+ precursors (NMN/NR)
- Senolytics and cellular cleanup
- Metformin and rapamycin
- Aging biomarkers
Who This Guide Is For
Designed for biohackers interested in longevity, health professionals who want to understand the latest research, and anyone looking for evidence-based strategies to age better.
This guide is part of StackedHealth's personal development series. Content is regularly updated to reflect the latest scientific advances. This does not constitute medical advice.